Genes and Mechanisms in Vertebrate Sex Determination
Editorial Reviews
Book Description
Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions.
Book Info
Univ. of Freiburg, Germany. Monograph imparting knowledge of the genetic and developmental processes involved in sex determination in vertebrates, since the isolation of the SRY gene in 1990. The edited papers are reprinted from Genes and Mechanisms in Vertebrate Sex Determination, in Cellular and Molecular Life Sciences 55:821-931. For students and researchers.
Genes and Mechanisms in Vertebrate Sex Determination,Gerd Scherer,Michael Schmid,Birkhauser,3764361689,Animal Genetics,Genetics,Life Sciences - Anatomy & Physiology,Life Sciences - Biology - Developmental Biology,Life Sciences - Zoology - General,Medical,Medical / Nursing,Physiology Of Reproduction,Research,Science,Sex determination, Genetic,Science / Biology
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